A medication challenge is performed when it is believed that a patient is allergic to a certain medication and is the cause of an allergy or skin related problem. The test is always performed by the direct supervision of our board-certified allergist/immunologist. A very small amount of the allergen is inhaled or ingested orally while the patient is monitored closely for any reactions. The dose is usually increased with toleration over a period of several hours. Examples of medication challenges are Tylenol, Advil, Penicillin, and local anesthesia. This is helpful in determining if a patient is truly allergic to a specific medication or just has intolerance to it.